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| Stability study of Shuxuetong injection in two common solvents |
| Hits 1961 Download times 1541 Received:March 26, 2019 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2019.04.06 |
| Key Words
Shuxuetong injection;clinical compatibility;stability study;injection vehicle |
| Author Name | Affiliation | E-mail | | XIE Jiarong | Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
The Institute of Traditional Chinese Medicine, Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China | | | MA Xutong | Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
The Institute of Traditional Chinese Medicine, Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China | | | YAN Hongli | Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
The Institute of Traditional Chinese Medicine, Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China | | | LIANG Chunxia | Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
The Institute of Traditional Chinese Medicine, Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China | | | PI Jiaxin | Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
The Institute of Traditional Chinese Medicine, Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China | ppstar9999@sina.com | | LIU Zhidong | Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
The Institute of Traditional Chinese Medicine, Tianjin University of Chinese Traditional Medicine, Tianjin 301600, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China | lonerliuzd@163.com |
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| Abstract
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| [Objective] To investigate the compatibility of Shuxuetong injection with 0.9% sodium chloride infusion and Shuxuetong injection with 5% glucose infusion.[Methods] According to the clinical dosage, Shuxuetong injection was added respectively to three types of 0.9% sodium chloride infusions and three types of 5% glucose infusions. Determine the content of hypoxanthine, appearance, pH, osmolality, insoluble particles, particle size and protein examination within 8 h after mixing.[Results] After the common solvents were mixed with Shuxuetong injection, the pH value, osmolality, insoluble particles and particle size were reasonable within 8 h. No protein substances were detected out. In the detection of hypoxanthine content, the content was stable within 2 h after mixing Shuxuetong injection with 0.9% sodium chloride infusion, and slowly degraded after 2 h. The content was stable within 8 h after mixing Shuxuetong injection with 5% glucose infusion.[Conclusion] After mixing Shuxuetong injection with 0.9% sodium chloride infusion and Shuxuetong injection with 5% glucose infusion, the indicators were basically stable within 8 h. So 0.9% sodium chloride infusion and 5% glucose infusion are suitable for the clinical compatibility of Shuxuetong injection. In addition, it is recommended to use it as soon as possible after mixing in clinical use. |
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