|
| The studies of the association between ABCA1 gene rs363717 with blood lipids and coronary heart disease susceptibility |
| Hits 2167 Download times 976 Received:April 20, 2019 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2019.04.13 |
| Key Words
ATP binding cassette subfamily A1;genetic polymorphism;blood lipid;coronary heart disease |
| Author Name | Affiliation | | YANG Bo | Tianjin Beichen Hospital, Tianjin 300499, China |
|
| Abstract
|
| [Objective] To explore the association between susceptibility to coronary heart disease (CHD) and polymorphism site genotype of ATP binding cassette transporter A1 (ABCA1) gene rs363717 in Chinese male Han population.[Methods] The subjects of this study include 165 patients meet the world health organization's definition and criteria for diagnosis of CHD, and 165 cases of healthy people (control group). The basic information of age, systolic pressure, diastolic pressure, serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, low density lipoprotein cholesterol levels, fasting plasma glucose whether to have high blood pressure, diabetes, smoking and drinking and other basic information of the two groups of subjects were collected through questionnaires and other methods. Determination of two groups of subjects ABCA1 gene rs363717 polymorphism loci of type and calculate the corresponding allele genotype frequency. The blood lipid level of the ABCA1 gene rs363717 polymorphism site in the CHD group was measured, and the association between the genotype frequency of ABCA1 gene rs363717 polymorphism and the severity of CHD in patients with coronary heart disease was analyzed. Whether the allele frequencies in the two groups of subjects meet the population representativeness was tested by Hardy Weinberg equilibrium.[Results] The A allele frequency (76.06%) of the polymorphism site of the ABCA1 gene rs363717 in the CHD group was higher than that in the control group (66.67%), and the difference was statistically significant (P<0.05);AA genotype and (AG+GG) genotypes in serum leels of total cholesterol, triglycerides, high-density lipoprotein cholesterol and low density lipoprotein cholesterol level were no significant difference (P>0.05). In addition, there was no correlation between the number of existing vascular lesions and the allele at the polymorphism site of ABCA1 gene rs363717.[Conclusion] ABCA1 gene rs363717 polymorphism loci may be associated with the onset of CHD, the G allele may be the protection sites of CHD. |
|
|
|
|
|
