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| Clinical study on the treatment of elderly lung adenocarcinoma with Chinese medicine combined with icotinib |
| Hits 1453 Download times 1022 Received:July 08, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.05.09 |
| Key Words
elderly advanced lung adenocarcinoma;traditional Chinese medicine;icotinib |
| Author Name | Affiliation | E-mail | | SHEN Liping | Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | LIU Lingshuang | Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | liuls107@163.com | | JIANG Yi | Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | GU Aiqin | Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, China | | | WU Qiongqian | Yongjia Traditional Chinese Medicine Hospital, Wenzhou 325100, China | | | ZHANG Yi | Shandong University of Traditional Chinese Medicine, Jinan 250014, China | |
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| Abstract
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| [Objective] To observe the efficacy and safety of traditional Chinese medicine combined with icotinib in elderly patients with advanced lung adenocarcinoma.[Methods] A prospective randomized controlled trial was performed in 74 patients with advanced lung adenocarcinoma of the elderly. The patients were divided into treatment group (TCM decoction decoction combined with icotinib 125 mg tid po) and control group (icotinib 125 mg tid po only),observed the side effects,quality of life,and statistics of disease Progression-free survival (PFS).[Results] 1)The ending of follow-up period was September 30 th,2018. The median PFS in the two groups was 15.4 months vs 13.13 months (P>0.05). In the subgroup analysis,the first-line therapists,the PFS were 16.90 months vs 13.13 months (P<0.05). 2)Adverse reactions:the main adverse reactions in the two groups were skin rash,diarrhea,liver damage, and oral ulcers. There was statistically significant difference in the occurrence of oral ulcers between the two groups (P<0.05). 3) After treatment for 1 month,the intragroup comparison of the quality of life of the two groups showed that the scores in the functional areas of the treatment group increased (P<0.05),and the scores in areas of fatigue, pain,shortness of breath,insomnia and other symptoms decreased (P<0.05). There was no change in scores in difficult economic areas,and scores of shortness of breath,cough,and pain in other parts of the lung cancer subscale decreased (P<0.05);scores in the emotional function,cognitive function,and social function of the functional areas of the control group increased (P<0.05). Pain,shortness of breath,loss of appetite,constipation and other symptoms decreased after treatment (P<0.05);in the subscale of lung cancer,the score of oral ulcers increased (P<0.05),and cough score decreased (P<0.05). Comparison between groups showed that the scores of physical function and total health of the treatment group were higher than those of the control group (P<0.05). In the subscale of lung cancer, the score of the oral ulcer was lower in the treatment group than in the control group (P<0.05).[Conclusion] TCM treatment can improve the clinical efficacy of icotinib in the treatment of advanced lung adenocarcinoma in the elderly to a certain extent. It can prolong the time of disease progression in first-line treatment of icotinib and does not increase the adverse reactions,and improve Oral ulcers after treatment with icotinib. |
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