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| Study on the dissolution rules and quality markers of active components in the extracts of paeonia-liquorice with different compatibility ratios |
| Hits 1534 Download times 1105 Received:April 05, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.05.18 |
| Key Words
shaoyao-gancao;compatibility ratio;active ingredient dissolution rate |
| Author Name | Affiliation | E-mail | | LIU Xiukun | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | CHEN Ying | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | RAN Qi | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | ZHAO Zhuozhuo | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | LI Nana | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | DING Hui | Tianjin Zhongyi Pharmaceutical Co. Ltd., Tianjin 300193, China | | | YU Heshui | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | LI Wei | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | MENG Fanying | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China | | | SONG Xinbo | Tianjin University of Traditional Chinese Medicine, Municipal Experimental Teaching Demonstration Center of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjian 301617, China
Tianjin Zhongyi Pharmaceutical Co. Ltd., Tianjin 300193, China | songxinbo@tjutcn.edu.cn |
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| Abstract
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| [Objective] By measuring the ratio of pH value,density,ointment rate,polysaccharide content and content of six active ingredients in different proportions of shaoyao-gancao decoction,the related indexes were studied with the variation of the compatibility change law,and exploring the quality markers of shaoyao-gancao pairs.[Methods] To determinate the paste rate,the ratio of pH value and density,separately. The determination was carried out with Kromasil 100-5-C18 column (250 mm×4.6 mm,5 μm). The mobile phase consisted of acetonitrile (B)-0.1% phosphoric acid aqueous solution (A) with gradient elution manner (0~8 min,14%~19%B,8~20 min, 19%~28% B,20~25 min,28%~35% B,25~30 min,35%~45% B,30~40 min,45%~95% B). The flow rate was 1.0 mL/min,the detection wavelength was 254 nm and the column temperature was 30℃.[Results] There was no significant relationship between the density and the pH value of the extract and the ratio (1:0,10:1,10:2,10:3,10:4, 10:5,10:6,10:7,10:8,1:1,1:2,1:3,1:4,1:6,1:8,0:1). The range of density change was 1.003±0.002,the range of pH change was 4.94±0.11,and the range of paste rate change was 15.39±1.70. In the decoction process of different proportions of shaoyao-gancao,the change trend of albiflorin and paeoniflorin in shaoyao was similar,and the change trend of liquiritin and glycyrrhizic acid in gancao was similar.[Conclusion] According to the results of different ratios of shaoyao-gancao extract pH,density,paste rate and content of six active ingredients. From the chemical composition level,it is scientific and reasonable to choose albiflorin,paeoniflorin,liquiritin and glycyrrhizic acid as the quality marker of shaoyao-gancao. |
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