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| Isolation and structural identification of lignans from fruits of Vitex trifolia L. var. simplicifolia Cham. |
| Hits 1639 Download times 912 Received:May 25, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.05.20 |
| Key Words
Vitex Fructus;lignans;chemical constituents;structural identification |
| Author Name | Affiliation | E-mail | | HUANG Yanli | Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | ZHANG Han | Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | GUO Ying | Tianjin Nankai Hospital, Tianjin 300100, China | | | LI Anping | Harmonia Testing(Tianjin) Co., Ltd, Tianjin 300457, China | | | YAO Jinlong | Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | DENG Yanru | Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | FANG Shiming | Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | fang_shiming@163.com |
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| Abstract
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| [Objective] To study the lignans from the fruits of Vitex trifolia L. var. simplicifolia Cham.[Methods] The chemical compounds were isolated and purified by Silica gel column,Sephadex LH-20,MCI,ODS and PHPLC (Preparative high performance liquid chromatography,PHPLC) chromatorgraphies and identified by chemical and spectral analysis 1H,13C-NMR (Nuclear magnetic resonance,NMR),COSY (Correlation spectroscopy,COSY),HMQC (1H detected heteronuclear multiple quantum coherence,HSQC),HMBC (1H detected heteronuclear multiple bond correlation,HMBC) and MS (Mass spectrometer,MS).[Results] Seven lignan monomers were isolated from 95% ethanol extract of Vitex trifolia L. var. simplicifolia Cham. and identified as dihydrodehydrodiconiferyl alcohol (1), ficusal (2),(7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (3),dihydrodehydrodiconiferyl alcohol-β-D-(2'-O-p-hydroxybenzoyl) glucoside (4),(7R,8R)-7,8-dihydro-9'-hydroxyl-3'-methoxyl-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol 9'-O-β-D-glucopyranoside (5),pinoresinol (6),1-syring-aresinol (7).[Conclusion] Compound 5 was obtained from Vitex genus firstly,and compounds 6,7 were isolated from the plant for the first time. |
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