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| Multi targeting anti-arrhythmic Chinese and western drugs: a therapeutic potential viewed from brain-heart axis |
| Hits 1435 Download times 1065 Received:April 10, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.05.22 |
| Key Words
Simultaneous treatment of brain and heart;multi-target anti-arrhythmia stroke |
| Author Name | Affiliation | E-mail | | SHI Xianru | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | WANG Taiyi | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | GAO Jiaming | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | MA Yuling | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | LI Ju | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianshili pharmaceutical group co., Ltd., Tianjin 300410, China | | | ZHU Yan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | yanzhu.harvard@icloud.com |
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| Abstract
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| Arrhythmia is one of the most common cardiac diseases with complicated etiology. The efficacy and side effects of various single-target antiarrhythmic drugs are highly variable. In addition to ion channel abnormalities in the heart,abnormal brain function (cortex),brainstem and autonomic nerve also can directly cause arrhythmia,can also affect cardiac electrophysiology and thus cause arrhythmia. The interactions between brain and heart mainly involve insular cortex,electrolyte and immune response related to autonomic nervous system. Clarifying the mechanism of cardio-cerebral interaction is helpful to explain random sudden cardiac events and may provide new insights into the treatment of arrhythmia. This review will focus on summarizing the pathophysiological pathways of arrhythmia caused by stroke,in order to find new targets that have regulatory effects on heart rhythm,and make a prospect of drugs that have effects on these targets and their clinical application prospects. |
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