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| A four-weeks sub-chronic toxicity study of the debris after decoction of Fructus Psoraleae by intragastric administration in rats |
| Hits 1570 Download times 875 Received:June 03, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.06.18 |
| Key Words
Fructus Psoraleae;hepatotoxicity;medicine residues |
| Author Name | Affiliation | E-mail | | WANG Zhaoxin | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Li | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LU Guoyan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yue | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Prescriptions, Ministry of Education, Tianjin 301617, China | | | YU Yingli | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Prescriptions, Ministry of Education, Tianjin 301617, China | yuguyu88@sina.com | | ZHOU Kun | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Prescriptions, Ministry of Education, Tianjin 301617, China | |
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| Abstract
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| [Objective] Compare the toxicities of crude drug and water extract residues of Fructus Psoraleaein male and female rats.[Methods] Female and male SD rats were randomly divided into 5 groups each according to body weight, with 7 rats in every group. The high and low dose groups of fructus soraleae crude drug, and the high and low dose groups of drug residues were administered by intragastric injection of 6 g/kg or 3 g/kg drug solution, respectively, for 4 weeks. Biochemical indicators were detected and the organ coefficients were calculated. The MDA and T-AOC levels in liver tissues were measured and the tissue damage were detected by histopathological examination.[Results] After 4 weeks of administration, the body weights of the crude drug groups were significantly decreased when compared with the control group. The liver and kidney coefficients both in the crude drug groups and in the residues groups were significantly decreased. In the crude drug groups, the MDA level increased significantly, and the thymus organ coefficient decreased significantly, while no significant difference was found in the residues groups. The T-AOC level in the high-dosedrug administration group and the dregs group of the male rats were significantly elevated compared with the control. Compared with the crude drug group, the liver coefficient and MDA of the dregs group significantly decreased, while the T-AOC of the male dregs low-dose group increased significantly.[Conclusion] The toxicity of Fructus Psoraleae aqueous extract residues is relative smaller than the crude drug. |
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