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Optimization of the processing technology of safflower processed with liquor by orthogonal test
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DOI   10.11656/j.issn.1673-9043.2019.06.19
Key Words   wine-washed safflower;orthogonaldesign;processing technology;content determination;fingerprint
Author NameAffiliationE-mail
LIU Caifeng School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China  
LIANG Jun School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China  
ZHONG Linying School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China  
ZHANG Qi School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China  
TIAN Wanwan School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China  
LIU Donghan School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China  
BAI Jie School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China baijie22811@163.com 
DU Shouying School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China dushouying@263.net 
HE Shuheng Yifan Pharmaceutical Co., Ltd., Lin'an 311300, China  
Abstract
    [Objective] To select the best processing method and parametersof safflower prepared with liquor, and thenprovide the basis for Scientific research.[Methods] The orthogonal experiment was carried out with hydroxysafflor yellow A and kaempferol as indicators.the effects of alcohol content, soaking time and drying temperature were investigatedon the processing of wine-washed safflower. The difference in content and fingerprint of water decoction were compared before and after processing.[Results] The best process parameters were as follows:the amount of alcohol is 50% (50 g wine per 100 g of medicine), soaking time is 30 min, and baking temperature is 40℃. After processing, the content of hydroxysafflor yellow A and kaempferol was lower than that in raw product, but the difference was small, the peak areas of most components in the decoction fingerprint were decreased, especially of the small polar components.[Conclusion] The preferred wine-washed safflower processing technology has good feasibility and good controllability, and is suitable for industrial production.

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