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| Research progress of sterol-regulatory element binding proteins in prostate cancer |
| Hits 1527 Download times 963 Received:June 05, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.06.23 |
| Key Words
prostate cancer;sterol-regulatory element binding proteins;lipid metabolism;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | CHEN Luyao | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GUO Yaping | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Zhaiyi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHENG Fang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Tao | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PENG Yanfei | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | pengyanfei@tjutcm.edu.cn |
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| Abstract
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| The disorder of lipid metabolism has been considered as a characteristic of prostate cancer (PCa). Sterol-regulatory element binding proteins (SREBPs) acted as vital transcription factors, which can regulate the expression of key genes for fatty acid and cholesterol synthesis. Previous reports indicated that SREBPs were potential therapeutic targets in prostate cancer treatment. This review summarizes the regulatory role of SREBPs in PCa progression and the present research advance in prostate cancer treatment by targeting SREBPs. |
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