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| Comparative study on anti-osteoporosis efficacy of epimedium water extract and its residue |
| Hits 1188 Download times 993 Received:July 25, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2020.01.19 |
| Key Words
epimedium;water extract;drug residue;osteoporosis;female rats |
| Author Name | Affiliation | E-mail | | ZHOU Yating | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Ying | Inner Mongolia Agricultural University, Hohhot 010018, China | | | BI Yanan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YUAN Xiaomei | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SONG Lei | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin 301617, China | | | ZHOU Kun | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin 301617, China | z.k.ken@263.net |
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| Abstract
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| [Objective] To compare the therapeutic effects of epimedium water extract and its residue after water extraction on osteoporosis in rats.[Methods] Fifty female SD rats underwent bilateral ovariectomy were randomly divided into five groups twelve weeks after operation:epimedium water extract 1 g/kg group (based on crude drugs,the same below),water extract 0.5 g/kg group,drug residue 1 g/kg group,drug residue 0.5 g/kg group and model group. Another ten SD rats were used as control group. Rats in each group were sacrificed after 8 weeks of continuous administration. Liver,kidney and uterus were weighed and organ index was calculated. Blood was taken for serum biochemical index detection,and tibia was taken for bone microstructure detection by Micro-CT.[Results] After 8 weeks of administration,the serum OC,PINP,CTX1 in each group had less significant difference compared with the model group,but had a tendency to recover to the normal level in the control group;ALT,AST,TC,TG and GLU had an increasing trend. CT scans showed that the bone volume,bone area,the number of bone trabeculae and the thickness of bone trabeculae in the drug group were significantly higher than those in the model group,and the bone microstructures in the 0.5 g/kg drug residue group were significantly higher than those in the 0.5 g/kg water extract group (P<0.05).[Conclusion] Epimedium water extract and its residue have therapeutic effect on osteoporosis induced by ovariectomy in female rats. The therapeutic effect of 0.5g/kg epimedium residue is better than that of the same dose of water extract. |
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