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| Study on the change regularity of the effective components of Salvia miltiorrhiza in different habitats |
| Hits 1401 Download times 853 Received:October 17, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2020.01.20 |
| Key Words
Salvia miltiorrhiza;different habitats;effective components;quality characteristics |
| Author Name | Affiliation | E-mail | | WANG Zhiqiang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Juan | Department of Pharmacy, Tianjin Nankai Hospital, Tianjin 300100, China | | | ZHAO Zhihong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CAO Lijuan | China Medico Corporation, Tianjin 300301, China | | | LI Xifan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Tianxiang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | litianxiang612@sina.com |
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| Abstract
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| [Objective] To investigate the change regularity of effective components of Salvia miltiorrhiza in different habitats and explore the quality characteristics of the medicinal materials in each habitat by determinating the content of effective components.[Methods] The content of total extract of Salvia miltiorrhiza was determined by hot dipping method (dilute ethanol as solvent) under the Pharmacopoeia 2015 (General Principles 2201). The content of total tanshinone and total salvianolic acid were determined by UV-VIS. The content of tanshinone ⅡA and salvianolic acid B were determined by HPLC-UV.[Results] The total extract content of Salvia miltiorrhiza in each habitat was higher than 50.0%. The total levels of effective components of Salvia miltiorrhiza in Shandong Linyi,Henan Fangcheng and Sichuan Zhongjiang were higher. The content of tanshinone ⅡA in some samples from Henan,Hebei,Shanxi and Sichuan is less than 0.25%,which is unqualified. The cultivated Salvia miltiorrhiza in Tianjin has a certain quality advantage because each characteristic component has reached the pharmacopoeia standard.[Conclusion] There are significant differences in the content of effective components of Salvia miltiorrhiza in different habitats. Among them,the content difference of tanshinone ⅡA is particularly obvious,which is the main reason for the unqualified quality of the medicine. Shandong Linyi,Shanxi Shangluo,Sichuan Zhongjiang,and Henan Fangcheng are the genuine production areas of Salvia miltiorrhiza,which is reasonable. The quality of the introduced and cultivated medicinal materials in the non-genuine production area is partially unqualified. Therefore,the extensive introduction of Salvia miltiorrhiza in the non-genuine production area deserves high attention. |
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