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| Preparation and physicochemical characterization of folic acid modified nanostructured lipid carrier loaded with tanshinone ⅡA |
| Hits 1640 Download times 832 Received:October 21, 2019 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2020.01.21 |
| Key Words
tanshinone ⅡA;nanostructure lipid carrier;folic acid |
| Author Name | Affiliation | E-mail | | LIU Jingjing | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xinyue | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Yumei | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MA Li | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Bing | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Zhidong | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lonerliuzd@163.com | | LI Jiawei | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-Established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lijiawei@163.com |
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| Abstract
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| [Objective] The nanostructured lipid carrier (NLC) loaded with tanshinone ⅡA was prepared and modified by inserting the DSPE-PEG-FA on its surface,and the physicochemical characterizations of the NLC were investigated.[Methods] The FA-TanⅡA-NLC was prepared by emulsification-evaporation technique. The particle size,zeta potential and encapsulation efficiency were used to preliminarily evaluate the NLC,which was further characterized by TEM,DSC and XRD.[Results] The particle diameter of FA-Tan ⅡA-NLC was of (19.14±0.43) nm, PDI was 0.424±0.01,and the zeta potential was of (-11.67±0.25) mV. The encapsulation efficiency was 99%. The results of DSC and XRD indicated that tanshinone ⅡA was encapsulated in the nanostructured lipid carrier in an amorphous form.[Conclusion] The FA-TanIIA-NLC prepared in this experiment had uniform particle size distribution,stable potential and high encapsulation efficiency. |
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