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| Effect of Tiaogan Huaxian Pill and entecavir on compensation period of hepatitis B cirrhosis |
| Hits 1390 Download times 2046 Received:October 02, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2020.02.11 |
| Key Words
liver cirrhosis;compensation period of hepatitis B;Tiaogan Huaxian Pill;Entecavir |
| Author Name | Affiliation | E-mail | | LI Nian | Guangxi University of Traditional Chinese Medicine, Nanning 530000, China | | | LI Yuan | Department of Hepatology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530002, China | | | ZHAO Kaijie | Guangxi University of Traditional Chinese Medicine, Nanning 530000, China | | | WANG Xiaoli | Guangxi University of Traditional Chinese Medicine, Nanning 530000, China | | | LUO Pengji | Guangxi University of Traditional Chinese Medicine, Nanning 530000, China | | | HUANG Guye | Department of Hepatology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530002, China | huangguye@163.com |
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| Abstract
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| [Objective] To observe the clinical efficacy of Tiaogan Huaxian Pill combined with entecavir in the treatment of compensatory hepatitis B virus (HBV) cirrhosis. [Methods] Based on prospective,randomized and controlled clinical study, the 84 patients with hepatitis B cirrhosis in compensatory phase were randomly divided into control group and treatment group. The 42 patients in control group took entecavir dispersible tablets 0.5 mg/d;the 42 patients in treatment group took entecavir dispersible tablets 0.5 mg/d;combined Tiaogan Huaxian Pill 10 g, 3 times one day for 36 weeks. The improvement of liver function before treatment and 36 weeks after treatment,the changes of LSM,HBV-DNA load and TCM syndrome integral were analyzed and compared. [Results] Before treatment,there was no significant difference in the scores of ALT,AST,TBIL,ALB,HBV-DNA,LSM and TCM symptoms (P>0.05). After 36 weeks of treatment,the ALT,AST and TBIL of the two groups were lower than those of the baseline (P<0.05),the treatment group was more significant (P<0.05),and that of the treatment group was lower than that of the baseline (P<0.05). ALB were higher than baseline,the treatment group increased more significantly (P<0.05). There was no significant difference in HBV-DNA negative conversion rate (<200 IU/mL) between the two groups after treatment (P>0.05). LSM and TCM symptom scores of the two groups after treatment were significantly lower than those before treatment (P<0.05). [Conclusion] Tiaogan Huaxian Pill combined with entecavir can significantly improve the TCM syndrome score and liver function of patients with compensatory hepatitis B cirrhosis,reduce liver hardness and DNA load,delay the progress of liver cirrhosis and improve the quality of life of patients. |
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