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| Effects of nuciferine on non alcoholic fatty liver disease and the relative mechanisms based on SREBP signaling pathway |
| Hits 1189 Download times 876 Received:January 29, 2020 |
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| DOI
10.11656/j.issn.1673-9043.2020.03.16 |
| Key Words
nuciferine;NAFLD;SREBP signaling pathway |
| Author Name | Affiliation | | HE Bing | The First People's Hospital of Qujing, Qujing 655000, China | | GAO Yanhong | The First People's Hospital of Qujing, Qujing 655000, China | | SUN Hua | The First People's Hospital of Qujing, Qujing 655000, China | | WANG Junling | The First People's Hospital of Qujing, Qujing 655000, China |
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| Abstract
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| [Objective] The aim of this study is to investigate the effects of active ingredient in lotus leaf on non alcoholic fatty liver disease (NAFLD) model mice and the relative mechanisms.[Methods] Mice was received high-fat diet to induce NAFLD. Meanwhile,mice were treated with different dosages of nuciferine orally. The effects of nuciferine on NAFLD were studied through measuring the body weight,serum biochemical markers after nuciferine treatment. The livers in each group were also stained with HE and oil red O to observe the pathological changes and lipid contents in liver. In addition,total RNAs in livers were isolated and the gene expression related to SREBP signaling pathway was measured using qPCR in order to study the underlying mechanisms of nuciferine on NAFLD.[Results] Nuciferine treatment significant decreased the body weight and serum levels of ALT,AST,TG and TC in NAFLD. Nuciferine could also attenuate the steatosis of hepatic cells and decrease the lipid content in liver. Compared with the NAFLD model mice,nuciferine treatment down-regulated the gene expression of SREBF-1,ACC,ACLY and FASN in liver.[Conclusion] Nuciferine could attenuate NAFLD in mice through inhibiting the activation of SREBP signaling pathway in liver. |
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