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| Study on the change law of major pharmacological components in Scutellariae Radix membranaceus from different habitats |
| Hits 1442 Download times 930 Received:January 25, 2020 |
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| DOI
10.11656/j.issn.1673-9043.2020.03.17 |
| Key Words
Scutellaria Radix;producing areas;medicinal composition;principal component analysis |
| Author Name | Affiliation | E-mail | | YANG Yang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Zhiqiang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | REN Lili | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Qiushuang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CAO Lijuan | Tianjin Shengshibai Herbal Medicine Co. Ltd., Tianjin 300301, China | | | LI Tianxiang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | litianxiang612@sina.com |
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| Abstract
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| [Objective] Through systematic investigation of the major medicinal ingredients content of Scutellariae Radix from 13 producing areas in 7 producing units and sample plots,the overall quality characteristics of Scutellariae Radix from different producing areas were confirmed,which provided reference for its clinical application.[Methods] The total extract content was determined by alcohol-soluble leaching method,and the contents of baicalin,wogonoside,and baicalein were determined by HPLC,and principal component analysis(PCA) was performed.[Results] Based on the baicalin and extracts in the Pharmacopoeia limited index components,the Scutellaria samples were higher than the pharmacopoeia limited standards. The content of cultivated Scutellaria in Linyi and Chifeng was the highest,but the wild Scutellaria was lower in all producing areas. The wogonoside content is between 2.28% to 3.74%,and the cultivated in Linyi still has the highest level,and the wild in other producing areas are lower. The content of baicalein is 0.3% to 1.0%,and the overall level of cultivar in Shanxi is higher.[Conclusion] PCA showed that the overall quality of Radix Scutellariae in the main producing areas was superior,and there were no unqualified medicinal materials. The medicinal ingredient accumulation of cultivated in Linyi,Shandong Province was the most abundant,followed by Shanxi Yuncheng,Wenxi and Xiaxian. It shows that Shanxi as a high-quality production area has a certain rationality in the current market;Fengning,Chengde and Chifeng wild varieties are in the last three places,and the cumulative medicinal ingredients amount of wild varieties in each producing area is much lower than that of cultivated varieties. This phenomenon should attract people's attention. |
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