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| Selection of suitable conditions in the stability study of animal Chinese medicinal materials：takinghirudoesand pheretimasas examples |
| Hits 1165 Download times 981 Received:January 14, 2020 |
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| DOI
10.11656/j.issn.1673-9043.2020.04.20 |
| Key Words
animal traditional Chinese medicine;stability test;hirudo;pheretima |
| Author Name | Affiliation | E-mail | | MA Xutong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicale, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Rescarch Cencer of Modern Chinese Medicine Discovery and preparation technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yiting | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicale, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Rescarch Cencer of Modern Chinese Medicine Discovery and preparation technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Ying | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicale, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Rescarch Cencer of Modern Chinese Medicine Discovery and preparation technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Liqiang | Mudanjiang Youbo Pharmaceutical Limited Liability Company, Mudanjiang 157000, China | | | PI Jiaxin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicale, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Rescarch Cencer of Modern Chinese Medicine Discovery and preparation technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | pijiaxin@tjutcm.edu.cn | | LIU Zhidong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicale, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Rescarch Cencer of Modern Chinese Medicine Discovery and preparation technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lonerliuzd@163.com |
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| Abstract
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| [Objective] The stability tests of hirudoes and pheretimas were carried out to investigate the quality fluctuation and change of hirudoes and pheretimas under the set conditions,so as to provide a reference for the reasonable evaluation of the storage conditions of animal traditional Chinese medicine and provide an important experimental basis for the selection of appropriate conditions for the stability study of this kind of medicine.[Methods] With reference to the stability guidelines,carry out influential factor tests on different batches of hirudoes and pheretimas,accelerated tests under conditions of[(30±2)℃,RH(65±5)%],and low temperature conditions[(6±2)℃],nine months long-term test under low humidity conditions[(25±2)℃,RH (40±5)%],and the corresponding inspection items were determined.[Results] In the influencing factors,acceleration and long-term experiments,the stability of the three batches ofhirudoesandpheretimas medicine met the quality standards.[Conclusion] Hirudoes andpheretimascan be used for stability test under accelerated test conditions of (30±2)℃,RH (65±5)% and long-term test conditions of low temperature[(6±2)℃] and low humidity[(25±2)℃,RH (40±5)%],which can also be used as an important reference for quality and stability research of other animal Chinese medicinal materials. |
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