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| Research progress of traditional Chinese medicine in the treatment of diabetic foot ulcer based on SOCS pathway |
| Hits 1101 Download times 771 Received:June 18, 2020 |
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| DOI
10.11656/j.issn.1673-9043.2020.05.24 |
| Key Words
diabetic foot ulcerations;inflammation;wound healing;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LIU Guotao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | WANG Jun | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | WangJ229@tjutcm.edu.cn |
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| Abstract
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| Diabetic foot ulcers (DFUs) is one of the serious complications of diabetes mellitus,with high morbidity and amputation rate. At present,the specific pathogenesis is still unclear. Related studies have shown that inflammation,infection and nutritional disorders together affect the prognosis of diabetic foot ulcer,inhibit the expression of related inflammatory pathways and cytokines,and promote the abscission of necrotic tissue to promote healing. In addition,the suppressor of cytokine signaling (SOCS) can participate in cytokine signal transduction,wound inflammation and healing process of DFUs by activating JAK-STAT signal pathway. In recent years,a large number of studies have found that the single drug and its active ingredients with the effect of "removing the decay and generating new" and the Chinese herbal compound have very good curative effect on DFUs. In recent years,the research on the specific mechanism of the treatment of DFUs by Chinese herbal medicine has become one of the hot spots of research. In this paper,the author reviewed the recent literature on the relationship between SOCS pathway and DFUs and the mechanism of traditional Chinese medicine in the treatment of DFUs. |
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