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| Isolatation of Antitumor metastasis indole alkaloids from Tetrastigma obtectum |
| Hits 1132 Download times 676 Received:August 20, 2020 |
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| DOI
10.11656/j.issn.1673-9043.2020.06.19 |
| Key Words
Tetrastigma obtectum;indole alkaloid;tetrastigmindole A and B;antitumor metastasis effect;isolate |
| Author Name | Affiliation | E-mail | | ZHAO Jing | Tianjin Vocational College of Bioengineering, Tianjin 300462, China | | | SHI Guoru | School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China | | | DUAN Hongquan | School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China | duanhq@tijmu.edu.cn。 |
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| Abstract
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| [Objective] Phytochemical investigation of the whole plant of Tetrastigma obtectumhas lead to the isolation of two new indole alkaloids.[Methods] Spectral analysis was used for identification. Compounds 1 and 2 were treated in the anti-tumor metastasis screening experiment in MDA-MB-231 cell lines.[Results] Two new indole alkaloids were found in Tetrastigma obtectum,named tetrastigmanine A (1) and B (2).[Conclusion] In the anti-tumor metastasis screening experiment in MDA-MB-231 cell lines,compounds 1 and 2 revealed positive effects on anti-tumor metastasis. |
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