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| Molecular network mechanism and key targets of Erzhi Pills inhibiting the growth of melanoma cells |
| Hits 1100 Download times 790 Received:October 10, 2020 |
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| DOI
10.11656/j.issn.1673-9043.2020.06.20 |
| Key Words
network pharmacology;Erzhi Pills;skin cutaneous melanoma;targets;molecular network mechanism |
| Author Name | Affiliation | | CHEN Jing | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Department of Dermatology, Tianjin 300250, China | | YANG Ning | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Department of Dermatology, Tianjin 300250, China | | ZHANG Yaxing | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Department of Dermatology, Tianjin 300250, China | | GAO Xiumei | Tianjin University of Traditional Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, State Key Laboratory of Component-based Chinese Medicine, Tianjin 301617, China |
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| Abstract
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| [Objective] To explore the molecular network mechanism and key targets of Erzhi Pills in inhibiting the growth of skin cutaneous melanoma based on network pharmacology.[Methods] The effective components of Erzhi Pills were screened through pharmacology database of traditional Chinese medicine system. The differential genes expression of melanoma cells and melanocytes was obtained in GEO database. The protein-protein interaction network was established by using the software of CytoScape 3.7.2,the melanoma pivotal genes was screened by using GEPIA and survival analysis was carried out. Through the enrichment and analysis of different genes in DAVID bioinformatics resources,the KEGG network was constructed.[Results] Twenty one kinds of Erzhi Pills effective components and 1889 skin cutaneous melanoma related targets were obtained. NFKBIA,the first key genes,which has a lower expression in every stage of skin cutaneous melanoma and significantly makes an impact on the survival time negatively. Metabolic pathways include TNF signaling pathway,IL-17 signaling pathway,Chemokine signaling pathway,etc.[Conclusion] Erzhi Pills can inhibit skin cutaneous melanoma by up regulating NFKBIA,and TNF signaling pathway is the most important signaling pathway. |
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