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| Effect of chemical components in Dachaihu Decoction on animal model of pancreatitis: a Bayesian network Meta analysis |
| Hits 1122 Download times 594 Received:March 07, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2021.03.15 |
| Key Words
Dachaihu Decoction;pancreatitis;network Meta analysis;quercetin;emodin;baicalin |
| Author Name | Affiliation | E-mail | | SUN Kaibin | Shandong University of Traditional Chinese Medicine, College of Pharmacy, Jinan 250355, China | | | ZHANG Xinyu | Shandong University of Traditional Chinese Medicine, College of Pharmacy, Jinan 250355, China | | | ZHANG Jiaxiang | Shandong University of Traditional Chinese Medicine, College of Pharmacy, Jinan 250355, China | | | HUANG Nana | The Second Hospital of Shandong University, Jinan 250033, China | | | SUN Rong | The Second Hospital of Shandong University, Jinan 250033, China
Shandong University, Institute of Advanced Medical Sciences, Jinan 250012, China | sunrong107@163.com |
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| Abstract
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| [Objective] To systematically evaluate the efficacy of chemical components in Dachaihu Decoction in the intervention of animal models of pancreatitis.[Methods] Computers were used to search databases such as CNKI,Wanfang Data,VIP,PubMed,Embase,Cochrane Library. The search time range was from database establishment to October 2019;all the retrieved documents were imported into NoteExpress software for screening and management,the quality of the included literature and data extraction,using Stata 16,GeMTC 0.14.3 and other software for statistical analysis.[Results] A total of 75 chemical components were collected and screened,and 1 870 documents were retrieved,and 36 articles were finally included in the literature,involving five chemical components. Network Meta analysis showed:reduction of pancreatic pathological scores,quercetin>emodin combined with baicalin>emodin>otreotide>baicalin>paeoniflorin>β-carotene;lowering serum amylase effect ranking,emodin>octreotide>baicalin>emodin combined with baicalin>quercetin>β-carotene;reduce the order of TNF-α effect,emodin>emodin combined with baicalin>octreotide>baicalin>paeoniflorin;reduce the sorting effect of IL-6,emodin>baicalin>paeoniflorin>emodin combined with baicalin>β-carotene.[Conclusion] The five chemical components in Dachaihu Decoction have significant effects on intervention of animal models of pancreatitis,reduction of pancreatic pathological scores,and reduction of serum amylase,TNF-α,and IL-6 levels,and are safe without adverse reactions. These five ingredients together form the material basis for the efficacy of Dachaihu Decoction in the treatment of pancreatitis and play a synergistic role in the treatment. In addition,different chemical components exert different effects on different indicators,suggesting that the five chemical components may have different approaches to the development of pancreatitis,and this may also be the scientific connotation of the compatibility of Dachaihu Decoction. This study provides a reliable reference for future research and needs more high quality clinical trials and more clinical samples further confirm the efficacy and safety of these five chemical components. |
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