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| Research progress on the protective mechanism of Notch signaling pathway in cerebral infarction |
| Hits 967 Download times 645 Received:March 09, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2021.03.24 |
| Key Words
Notch signaling pathway;cerebral infarction;protective mechanism |
| Author Name | Affiliation | E-mail | | MA Han | Institute of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Traditional Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China | | | LI Jing | Institute of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Traditional Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China | 1725155193@qq.com |
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| Abstract
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| Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism,which affects many processes of differentiation during embryonic and postnatal development,and plays an important role in maintaining the value-added differentiation of neural stem cells,regulating keratinocyte production and participating in neuronal migration. Recent studies have confirmed that activation of Notch signal pathway promote generation of vascular cells,regulate the proliferation of neural stem cells and reduce the inflammatory response after cerebral infarction. It plays an important role in angiogenesis,repair of nervous system damage and reduction of immune cell infiltration in vascular ischemic area. In this paper,the physiological function of Notch signaling pathway in brain tissue and the mechanism of action in cerebral infarction are discussed,and the regulatory effect of acupuncture and Chinese traditional medicine on Notch signaling pathway is summarized to provide a new target for the treatment of cerebral infarction. |
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