|
| Effect of Chinese medicine cyclical therapy combined with aspirin and prednisone on clinical outcome of patients with recurrent implantation failure in the FET cycle |
| Hits 1092 Download times 568 Received:March 20, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2021.04.15 |
| Key Words
recurrent implantation failure;traditional Chinese medicine cycle therapy;aspirin;prednisone;frozen thawing embryo transfer;pregnancy outcome;kidney deficiency syndrome |
| Author Name | Affiliation | E-mail | | LIU Fen | Department of Gynecology, Traditional Chinese Medicine Hospital of Taihe County, Fuyang 236000, China | | | JIANG Tianfeng | Department of Gynecology, Traditional Chinese Medicine Hospital of Taihe County, Fuyang 236000, China | | | WU Limin | Reproductive Center of the First Affiliated Hospital of USTC, Reproductive Center of the First Affiliated Hospital of the University of China, Hefei 230001, China | wuliminmail@126.com | | TONG Xianhong | Reproductive Center of the First Affiliated Hospital of USTC, Reproductive Center of the First Affiliated Hospital of the University of China, Hefei 230001, China | | | LIU Yusheng | Reproductive Center of the First Affiliated Hospital of USTC, Reproductive Center of the First Affiliated Hospital of the University of China, Hefei 230001, China | |
|
| Abstract
|
| [Objective] To explore the effect of Chinese medicine cyclical therapy combined with aspirin and prednisone on the clinical outcomes of patients with recurrent implantation failure in the FET cycle. [Methods] From January 2017 to June 2017, the 178 patients with RIF (kidney deficiency syndrome) admitted to Anhui Provincial Hospital were selected as the study subjects forrandomised analysis, and were randomly divided into group A, group B and group C. Group A (control group) received routine FET cycle endometrial preparation. Group B (aspirin and prednisone group) received low-dose aspirin and prednisone after transplantation on the basis of group A. Group C(traditional Chinese medicine +aspirin and prednisonegroup) was treated with Chinese medicine on the basis of group B for 3 cycles before entering the cycle. The general clinical data, thickness and type of endometrial thickness and types of clinical outcomes were compared between the three groups. [Results] There was no significant difference in age, infertility, BMI, basal sex hormone FSH, LH, E2, number of previous failure cycles, number of embryos previously transplanted, number of embryos transplanted during this cycle, the number of high quality embryos transplanted in this period, embryo transfer type, abortion rate and multiple pregnancy rate between the three groups(P>0. 05). The thickness of endometrium and type A+B endometrium in group C were significantly better than group A and before treatment (P<0. 01). Type A+B endometrium in group B increased compared with group A and before treatment (P<0. 05). The embryo implantation, biochemical pregnancy, clinical pregnancy and abortion rate in group C were better than those in group B and group C, but the difference was not statistically significant (P>0. 05). In group C, the clinical pregnancy rate of RIF patients under 35 years old was significantly higher than that in group A (P<0. 05). [Conclusion] Chinese medicine cyclical therapy combined with aspirin and prednisone can improve endometrial thickness and type, improve endometrial receptivity and is beneficial to embryo implantation, especially under 35 years old. |
|
|
|
|
|
