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| Study on gender differences in the pharmacokinetics of isopsoralen in rats |
| Hits 874 Download times 564 Received:March 03, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2021.04.20 |
| Key Words
isopsoralen;pharmacokinetics;single administration;gender differences |
| Author Name | Affiliation | E-mail | | HUO Xiangxiang | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MEN Weijie | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Li | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yue | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 301617, China | | | ZHOU Kun | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 301617, China | z.k.ken@263.net |
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| Abstract
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| [Objective] Comparison of pharmacokinetics between female and male rats after single intragastric administration of isopsoralen. [Methods] Determination of rat plasma drug concentrations at different time points after single gavage of 56, 28, 14 and 7 mg/kg psoralen in female and male rats, and calculate the corresponding pharmacokinetic parameters. [Results] After a single intragastric administration of 4 different doses isopsoralen, there were differences in the t1/2, Cmax, AUC and other parameters in the plasma of rats of different gender. [Conclusion] There are gender differences in the pharmacokinetic characteristics of rats after intragastric administration of different concentrations of isopsoralen. |
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