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| Study on the mechanism of qi-regulating,phlegm-resolving,and blood-promoting prescription in treating cardiac syndrome X Based on network pharmacology |
| Hits 1013 Download times 536 Received:April 20, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2021.04.21 |
| Key Words
network pharmacology;qi-regulating,phlegm-resolving,and blood-promoting prescription;cardiac syndrome X;signaling pathway |
| Author Name | Affiliation | E-mail | | YANG Zhihua | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | YAN Haifeng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | GE Zhao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | CHEN Haojia | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Xianliang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | xlwang1981@126.com | | MAO Jingyuan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | jymao@126.com |
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| Abstract
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| [Objective] Using network pharmacology to analyze the molecular mechanism of qi-regulating, phlegm-resolving, and blood-promoting prescription in the treatment of Cardiac Syndrome X. [Methods] We obtained the chemical constituents and targets of 12 traditional Chinese medicines of qi-regulating, phlegm-resolving, and blood-promoting prescription from the TCMSP platform, and the targets of Cardiac Syndrome X were obtained from TTD, Drugbank and DisGeNET databases. To screen the common targets, we used Venn analysis to analyze the target of Cardiac Syndrome X and drug targets. Then, we used Cytoscape 3. 5. 1 software to create component-target network and component-target gene-pathway-disease network. A protein-protein interaction network was constructed through the STRING database. Finally, we performed GO enrichme nt analysis and KEGG pathway enrichment analysis on common targets by using the DAVID(6. 8) online analytical data tool. [Results] We screened out 165 chemical components of qi-regulating, phlegm-resolving, and blood-promoting prescription and 35 key targets which are related to the treatment of Cardiac Syndrome X. These key targets mainly involve processes such as inflammatory response, cell proliferation and apoptosis, substance metabolism, hormone secretion, regulating signaling pathways such as TNF, MAPK, IL-17, TLRs, NLRs, HIF-1, TCR, and PI3K-Akt to treat the Cardiac Syndrome X. [Conclusion] The results showed that qi-regulating, phlegm-resolving, and blood-promoting prescription mainly treats cardiac syndrome X with multi-component, multi-target and multi-channel synergistic effects such as anti-inflammatory action, anti-oxidation, anti-ischemia, protection of vessel endothelium, regulation of metabolise. This research research will lay the foundation for clinical application and further study of its pharmacodyna-micmechanism. |
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