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| Effect of Tongfei Huatan Decoction on serum LCN1 and LCN2 levels in patients with acute exacerbation of COPD of phlegm heat stagnation type |
| Hits 844 Download times 555 Received:June 02, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2021.05.13 |
| Key Words
Tongfei Huatan Decoction;AECOPD;phlegm heat damming lung syndrome;LCN1;LCN2 |
| Author Name | Affiliation | E-mail | | JIANG Wenshuai | Respiratory Department, Qingdao Chengyang District People's Hospital, Qingdao 266109, China | | | GAO Yuan | Respiratory Department, Qingdao Chengyang District People's Hospital, Qingdao 266109, China | | | SHI Lin | Respiratory Department, Qingdao Chengyang District People's Hospital, Qingdao 266109, China | | | LI Kefen | Respiratory Department, Qingdao Chengyang District People's Hospital, Qingdao 266109, China | | | DAI Xianhui | Respiratory Department, Qingdao Chengyang District People's Hospital, Qingdao 266109, China | jiangwenshuai0908@163.com |
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| Abstract
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| [Objective] To observe the clinical effect of Tongfei Huatan Decoction on the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) of phlegm heat stagnation type and the effect on the levels of serum LCN1 and LCN2.[Methods] The 80 patients with acute exacerbation of AECOPD were randomly divided into two groups:the control group and the treatment group (40 cases in each group). The two groups were treated with basic treatment such as oxygen inhalation and anti infection. The control group was treated with theophylline sustained-release tablets and salmeterol ticasone powder inhalation. The treatment group was treated with Tongfei Huatan Decoction on the basis of the control group. After the treatment, the two groups were compared with each other changes of bed efficacy, lung function, TNF-α, IL-8, LCN1 and LCN2 levels.[Results] After treatment, the total effective rate of the treatment group (90%) higher than that of the control group (72.5%, P<0.05). After treatment, the pulmonary function of the two groups was higher than that of the control group (P<0.05);the levels of TNF and IL-8 were lower than that of the control group (P<0.05);after treatment, the levels of LCN1 and LCN2 were lower than that of the control group (P<0.05). There were no adverse reactions during the treatment.[Conclusion] Tongfei Huatan Decoction was effective and safe in the treatment of acute exacerbation of COPD of phlegm heat stagnation type. It can obviously improve the lung function, reduce the levels of TNF-α, IL-8, LCN1 and LCN2, and improve the clinical effect. |
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