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| Quality evaluation of bran-processed Atractylodis Rhizoma standard decoction |
| Hits 891 Download times 550 Received:April 22, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2021.05.21 |
| Key Words
bran-processed Atractylodis Rhizoma;standard decoction;extraction ratio;transfer rate;fingerprint spectrum |
| Author Name | Affiliation | | ZHOU Nan | National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co. Ltd., Beijing 101300, China
Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101300, China | | ZHANG Zhiqiang | National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co. Ltd., Beijing 101300, China
Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101300, China | | ZHOU Yongkang | National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co. Ltd., Beijing 101300, China
Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101300, China | | YAN Xiaoxin | National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co. Ltd., Beijing 101300, China
Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101300, China | | CHENG Liwei | National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co. Ltd., Beijing 101300, China
Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101300, China | | DONG Chenhong | National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co. Ltd., Beijing 101300, China
Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101300, China |
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| Abstract
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| [Objective] To establish the quality evaluation method for bran-processed Atractylodis Rhizoma standard decoction, and to provide reference for the quality control of common dosage forms such as Atractylodis Rhizoma decoction and formula granule.[Methods] A total of 18 batches of qualified Atractylodis Rhizoma pieces were collected, and the corresponding standard decoction were prepared. The content of chlorogenic acid was determined by UPLC, and the corresponding transfer rate and extraction ratio were calculated. The UPLC fingerprint spectrum of bran-processed Atractylodis Rhizoma standard decoction was established, and the chemical structures of commom peaks were identified with liquid chromatography-mass spectrometry (LC-MS).[Results] The extraction rates of 18 batches of bran-processed Atractylodis Rhizoma standard decoction were 30.4%~41.4%, the contents of chlorogenic acid were 0.121~0.745 mg/g, and the transfer rates were 30.7%~79.5%. The characteristic atlas of the bran-processed Atractylodis Rhizoma standard decoction has 18 common peaks, the similarity of 18 batches of samples were all higher than 0.9, and the common peaks were identified, including 5-HMF, Chlorogenic acid, Caffeic acid.[Conclusion] The preparation technology of bran-processed Atractylodis Rhizoma standard decoction is standard and stable, the precision, stability and repeatability of the method are good, which can provide references for the quality control of terminal products from bran-processed Atractylodis Rhizoma decoction. |
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