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| Advances in research of traditional Chinese medicine regulating “APP metabolic pathway” in the treatment of Alzheimer's disease |
| Hits 1273 Download times 1269 Received:September 09, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2021.06.25 |
| Key Words
Alzheimer's disease;APP metabolic pathway;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LIAN Yunzhuo | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Linlin | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | CHENG Ruzhen | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SUN Weiming | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | XU Jiachun | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | WANG Kai | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | 15822947052@163.com |
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| Abstract
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| The abnormal metabolism of amyloid precursor protein (APP) leads to the deposition of β-amyloid peptide Aβ,which is closely related to the occurrence and development of Alzheimer's disease (AD). Finding potential drugs involved in the regulation of APP metabolic pathways for the treatment of AD is one of the hotspots in the field of Alzheimer's disease research. In recent years,the research progress of different targets in the regulation of "APP metabolic pathway" by traditional Chinese medicine has been reviewed,and the mechanism of action of traditional Chinese medicine in treating AD has been explored,which provides experimental basis for traditional Chinese medicine to participate in the prevention and treatment of AD. |
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