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| Effect of Shenxiang Suhe Pills on intestinal flora in rats with myocardial infarction |
| Hits 708 Download times 641 Received:October 11, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2022.01.17 |
| Key Words
Shenxiang Suhe Pill;myocardial infarction;intestinal flora |
| Author Name | Affiliation | E-mail | | WEI Xing | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIE Tian | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHONG Xinqin | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Xin | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | xinaw26@tju.edu.cn | | WANG Xiaoying | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wxy@tjutcm.edu.cn |
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| Abstract
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| [Objective] Explore the effect of Shenxiang Suhe Pills on the intestinal flora of rats with myocardial infarction.[Methods] The 16S amplicon sequencing technology was used to detect the changes of the intestinal flora of the rats with myocardial infarction in each group 14 days after the administration of Shenxiang Suhe Pills, the influence of Shenxiang Suhe Pills on key intestinal microorganisms was detected by in vitro culture experiments.[Results] Shenxiang Suhe Pills can improve the intestinal flora of rats with myocardial infarction, mainly by reducing the abundance of Firmicutes in the intestine of rats with myocardial infarction, increasing the abundance of Bacteroidetes, and reducing the abundance of the ratio of Firmicutes/Bacteroides;reducing the abundance of Streptococcus, Romboutsia, Lachnospiraceae, and Monoglobus(P<0.05);significantly increasing the abundance of Roseburia and Lactococcus(P<0.05). In addition, Lactobacillus is the dominant flora in the intestine, and Shenxiang Suhe Pills can up-regulate its abundance. The results of in vitro experiments showed that Shenxiang Suhe Pills can increase the growth rate of Lactobacillus johnsonii EU03 and Lactobacillus murinus EU04.[Conclusion] Shenxiang Suhe Pills can improve the intestinal flora of rats with myocardial infarction, especially promoting the growth of intestinal probiotics. It is speculated that the intestinal probiotics may be the potential targets of Shenxiang Suhe Pills in the treatment of myocardial infarction. |
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