|
| Preparation and in vivo intestinal absorption evaluation of baicalin-berberine complex nanocrystals |
| Hits 771 Download times 575 Received:October 15, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2022.01.20 |
| Key Words
traditional Chinese medicine;nanocrystals;baicalin;berberine;in situ single-pass intestinal perfusion model;absorption |
| Author Name | Affiliation | E-mail | | LIU Yiting | State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MA Xutong | State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jilin | State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PENG Hui | State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PI Jiaxin | State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | pijiaxin@tjutcm.edu.cn | | LIU Zhidong | State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liuzhidong@tjutcm.edu.cn |
|
| Abstract
|
| [Objective] To investigate the intestinal permeability improvement of baicalin-berberine complex nanocrystals.[Methods] Baicalin-berberine complex nanocrystals were prepared by anti-solvent methodfollowed by high pressure homogenization, and the in situ single-pass intestinal perfusion model was established to evaluate the absorption enhancement of the complex nanocrystals.[Results] Baicalin-berberine complex nanocrystals were prepared and characterized. The baicalin-berberine complex nanocrystals were cylindrical with the particle size at (225.10±9.12) nm, and the Polymer dispersity index was (0.27±0.04). In duodenum, jejunum, ileum and colon, the effective permeability coefficients (Peff) of baicalin in nanocrystals group were 2.99, 2.00, 2.66 and 5.58 times higher than that of coarse suspension group, separately. The Peff of berberine in nanocrystals group were 1.25, 1.18, 1.53 and 1.80 times higher than that of coarse suspension group, respectively.[Conclusion] Nanocrystals could improve the oral absorption of baicalin-berberine complex. |
|
|
|
|
|
