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| Clinical effect of modified Shengjiang Powder in patients with Ⅳ-stage diabetic nephropathy |
| Hits 730 Download times 426 Received:November 12, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2022.02.13 |
| Key Words
diabetic kidney disease;modified Shengjiang Powder;clinical effects;total efficiency;inflammatory cytokines |
| Author Name | Affiliation | E-mail | | CHENG Liying | Henan University of Traditional Chinese Medicine, Zhengzhou 450064, China | | | ZHANG Zhu | Department of Nephrology, Fuwai Huazhong Cardiovascular Hospital, Zhengzhou 451464, China | | | MA Jiwei | Department of Nephrology, the First Affiliated Hospital of Henan of Traditional Chinese Medicine, Zhengzhou 450003, China | jiwei193074@126.com | | WANG Qin | Henan University of Traditional Chinese Medicine, Zhengzhou 450064, China | | | LIU Haofei | Department of Nephrology, the First Affiliated Hospital of Henan of Traditional Chinese Medicine, Zhengzhou 450003, China | | | LUO Weixian | Department of Traditional Chinese Medicine, Zhengzhou First People's Hospital, Zhengzhou 450000, China | |
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| Abstract
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| [Objective] To investigate the clinical efficacy of Modified Shengjiang Powder in patients with Mid-stage diabetic nephropathy(DN). [Methods] The 80 cases of mid-stage DN patients with qi deficiency,blood stasis,and damp-heat are randomly divided into observation group and control group,with 40 cases in each group. The two groups were treated with routine diabetes education,hypoglycemia,blood pressure control,lipid regulation and other basic treatments. The observation group was combined with the control group to receive Modified Shengjiang Powder for a course of 12 weeks. The total response rate,24 h urinary protein level(24 h UP),serum creatinine (Scr),urea nitrogen (BUN),interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α) were compared between the two groups before and after treatment. [Results] Before treatment,there were no statistically significant differences in baseline data,related clinical indicators and inflammatory cytokines between the two groups(P<0.05). After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05),24 h UP,Scr,BUN,IL-1β,IL-6 and TNF-α levels were significantly lower than those in control group (P<0.001) and did not increase adverse events in patients. [Conclusion] Modified Shengjiang Powder has significant clinical effects in adjuvant treatment of patients with mid-stage DN. It can not only further enhance the total effective rate of patients,reduce inflammation,improve renal function,but also has good safety. |
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