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| Degradation kinetics of five iridoid glycosides in Ligustrum lucidum |
| Hits 662 Download times 422 Received:December 18, 2021 |
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| DOI
10.11656/j.issn.1673-9043.2022.02.21 |
| Key Words
ligustrum lucidum;stability;iridoid glycosides;chemical kinetics |
| Author Name | Affiliation | E-mail | | LIU Meiqi | College of Chinese Materia, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIU Ziying | College of Chinese Materia, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Dongping | State Key Laboratory for Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | REN Xiaoliang | College of Chinese Materia, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Meng | State Key Laboratory for Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SUN Lili | College of Chinese Materia, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | sunlili0114@tjutcm.edu.cn |
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| Abstract
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| [Objective] To study the degradation kinetic characteristics of five iridoid glycosides in Ligustrum luciduml in aqueous solution under different temperature,acid and base,light intensity and metal ion. [Methods] Ultra-high liquid chromatography(UPLC) was used to investigate the changes of the contents of five components with time in different environments. The degradation equation and a series of reaction kinetic parameters were obtained by chemical reaction kinetics method and the degradation law was summarized. [Results] The degradation rates of the five components were consistent with the first-order kinetic model under various conditions,and the degradation rate increases with increasing temperature. In addition,the other four components except nuezhenidic acid were stable under neutral condition,and the acid and alkalinity could be degraded to different degrees. Both UV lamp and fluorescent lamp could accelerate the degradation of the five monomer components in different degrees. Compared with aqueous solution,the half-life of the five monomer components was obviously shortened in metal ion environment,and the degree of degradation rate was Fe3+>Fe2+>Na+. [Conclusion] The five iridoid glycosides in Ligustrum lucidum are unstable,and their stability is affected by acid and alkali,high temperature,and illumination. During transportation or storage,it is necessary to avoid long-term light exposure,keep low temperature,pH near neutral,and avoid contact with metal ions,especially Fe3+。 |
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