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| Efficacy of Gouteng Yinzi with Xiaoqinglong Decoction in the dialectical treatment of cough variant asthma (pathogenic wind invading the lung) and its influence on levels of peripheral blood leukotriene D4 and C4 and urinary leukotriene E4 |
| Hits 704 Download times 431 Received:January 17, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2022.03.10 |
| Key Words
Gouteng Yinzi with Xiaoqinglong Decoction;cough variant asthma;lung function;leukotriene;urinary leukotriene |
| Author Name | Affiliation | | FU Qiongfang | Department of Traditional Chinese Medicine, Haikou People's Hospital, Haikou 570208, China | | HU Peng | Department of Traditional Chinese Medicine, Haikou People's Hospital, Haikou 570208, China | | YANG Wenxiu | Department of Traditional Chinese Medicine, Haikou People's Hospital, Haikou 570208, China | | CHEN Xiangsui | Department of Traditional Chinese Medicine, Haikou People's Hospital, Haikou 570208, China | | WANG Junna | Department of Traditional Chinese Medicine, Haikou People's Hospital, Haikou 570208, China |
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| Abstract
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| [Objective] To explore the effects of Gouteng Yinzi with Xiaoqinglong Decoction in the dialectical treatment of cough variant asthma (pathogenic wind invading the lung) and its influence on levels of peripheral blood leukotriene D4 (LTD4) and leukotriene C4 (LTC4) and urinary leukotriene E4 (LTE4).[Methods] Totally 100 patients with cough variant asthma in the hospital were selected as the research subjects, and they were divided into control group and observation group according to the simple random number table method. Control group (n=50) was given Montelukast Sodium Tablets and Salmeterroticasone powder inhaler, and observation group was additionally treated with Gouteng Yinzi with Xiaoqinglong Decoction on the basis of control group. The clinical efficacy, improvement status of traditional Chinese medicine(TMC) symptoms, lung function[forced expiratory volume (FEV1), peak expiratory flow rate (PEF), forced vital capacity (FVC)], levels of peripheral blood inflammatory factors[leukotriene D4 (LTD4), leukotriene C4 (LTC4), urinary leukotriene E4 (LTE4), serum eosinophil (serum EOS), immunoglobulin (IgE)] and adverse drug reactions after 2 months of treatmentand prognosis within 6 months after the end of treatment were compared between the two groups.[Results] After 2 months of treatment, the TCM efficacy of observation group was significantly better than that of control group(P<0.05). The TCM syndromes scores were significantly reduced (P<0.05), and the syndromes scores of observation group were significantly lower than those of control group(P<0.05). The levels of lung function indexes FEV1, PEF and FVC in the two groups were significantly increased(P<0.05) while the levels of peripheral blood LTD4, LTC4 and LTE4, serum EOS and IgE were significantly decreased(P<0.05), and there were significant differences in the above indicators between the groups after treatment (P<0.05). During treatment, there were no significant differences in the incidence rates of adverse reactions between the two groups(P>0.05). During follow-up within 6 months after the end of treatment, there were 13 cases of recurrence in control group with a recurrence rate of 26.00%, and there were 4 cases of recurrence in observation group with a recurrence rate of 8.00% (P<0.05).[Conclusion] Gouteng Yinzi with Xiaoqinglong Decoction is clinically effective and safe in the treatment of cough variant asthma of pathogenicevil invading the lung syndrome, and it can significantly improve symptoms, enhance lung function and inhibit inflammatory factors, with low recurrence rate. |
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