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| An acute toxicity study of psoralen,isopsoralen and bakuchiol in different gender |
| Hits 866 Download times 565 Received:February 27, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2022.03.20 |
| Key Words
psoralen;isopsoralen;bakuchiol;acute toxicity;gender differences |
| Author Name | Affiliation | E-mail | | YU Ruili | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHOU Yating | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yue | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Traditional Chinese Medicine and Pharmacology, Tianjin 301617, China | | | YU Yingli | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Traditional Chinese Medicine and Pharmacology, Tianjin 301617, China | yuguyu88@sina.com | | ZHOU Kun | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Traditional Chinese Medicine and Pharmacology, Tianjin 301617, China | |
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| Abstract
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| [Objective] To investigate the gender differences in acute toxicity of psoralen, isopsoralen and bakuchiol in mice.[Methods] The doses of psoralen were female (1 125, 843, 633, 475, 356 mg/kg) and male (633, 475, 356, 267, 200 mg/kg). For isopsoralen, the doses were female (404, 343, 292, 248, 210 mg/kg), male (317, 292, 269, 248, 229 mg/kg) and the doses of psoralen were 2 000, 1 765, 1 500, 1 200, 1 020 mg/kg for both. The test drugs were administered by intragastric administration, and the toxic effects, body mass and death of the mice were observed and recorded for 14 days. SPSS statistical software was used to calculate the LD50 and 95% confidence limit of the median lethal dose by Probit regression.[Results] The toxicity of the mice after administration was mainly convulsions, limbs and straightness, and the abdomen was attached to the ground. Some animals had secretions around the eyes. The higher the dose, the more obvious the reaction. Compared with the control group, the body weight of the mice in the psoralen and isopsoralen administration groups decreased with increasing dose. The LD50 of psoralen female mice was 514.35 mg/kg;the LD50 of male mice was 421.37 mg/kg, and the LD50 value of female mice was 22% higher than that of males. The LD50 of female mice with isopsoralen was 258.02 mg/kg;the LD50 of male mice was 255.26 mg/kg. The LD50 of bakuchiol female mice exceeded 2 000 mg/kg;the LD50 of male mice was 1 679.4 mg/kg.[Conclusion] There is a gender difference in the acute toxicity of psoralen and bakuchiol in mice, but without statistical significance. |
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