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| Study on immunomodulatory effect of Fuzheng Capsule extract on immunocompromised mice induced by cyclophosphamide |
| Hits 614 Download times 329 Received:March 03, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2022.04.11 |
| Key Words
Fuzheng Capsule extract;cyclophosphamide;immunosuppression;lymphocytesubpopulation |
| Author Name | Affiliation | E-mail | | CHEN Ting | Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China | | | CHENG Xudong | Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China | | | HU Fang | Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China | | | CHEN Ting | Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China | | | ZHU Hui | Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China | | | TANG Liang | Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China | 474975549@qq.com |
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| Abstract
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| [Objective] To investigate the regulation effect of Fuzheng Capsule extract on immune function of immunosuppressed mice.[Methods] Sixty Kunming mice were randomly divided into blank group, model group, positive control group, and Fuzheng Capsule extract low-dose, medium-dose and high-dose groups with 10 mice in each group.The immunocompromise model of mice was established by intraperitoneal injection of cyclophosphamide. Thymus index and spleen index, monocyte phagocytic, serum levels of Interleukin 4 (IL-4), Interleukin 10 (IL-10), Interleukin 17 (IL-17), Tumor necrosis factor alpha (TNF-α), Interferon gamma (IFN-γ) and the distribution and proportion of CD3+T lymphocytes(CD3+), CD4+T lymphocytes (CD4+)、CD8+T lymphocytes (CD8+).[Results] Fuzheng capsule extract can improve the thymus index and spleen index of immunosuppressed mice induced by cyclophosphamide, enhance the phagocytic function of monocytes, significantly increase the contents of cytokines IL-4, IL-10, IFN-γ, and decrease the contents of IL-17, TNF-α.The expression of CD3+CD4+ and the ratio of CD3+CD4+/CD3+CD8+ were up-regulated.[Conclusion] Fuzheng Capsule extract can improve the immune function of immunosuppressed mice induced by cyclophosphamide. |
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