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| Clinical observation of Shenshuai Formulation in treating 90 cases of CKD stage 4 patients with spleen and kidney qi deficiency wet turbidity inherent syndrome |
| Hits 691 Download times 318 Received:May 10, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2022.05.06 |
| Key Words
CKD stage 4;Yiqi Jiangzhuo Huoxue method;Shenshuai Formulation |
| Author Name | Affiliation | E-mail | | HAN Yu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | ZHANG Jing | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Yaoguang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | wangyaoguang1012@126.com | | ZHAO Xi | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | |
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| Abstract
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| [Objective] To observe the intervention effect of Shenshuai Formulation combined with aldehyde oxygen starch capsules and valsartan tablets on residual renal function and quality of life in patients with CKD stage 4.[Methods] A total of 90 patients with CKD stage 4 admitted to our hospital from October 2020 to September 2021 were randomly divided into the control group(45 cases) and the traditional Chinese medicine group(45 cases) according to the random number table method. The control group was treated with Aldehyde Oxygen Starch Capsule and Valsartan Tablet, and the traditional Chinese medicine group was treated with Shenshuai Formulation combined with Aldehyde Oxygen Starch Capsule and Valsartan Tablet. The course of treatment in each group was 3 months. The clinical efficacy, Scr, BUN, GFR, 24 h urine protein quantification, changes in ALT, AST, and adverse reactions were observed in the two groups before and after treatment.[Results] After 3 months treatment, the total effective rate of the traditional Chinese medicine group was 82.2%, while that of the control group was 62.2%. The clinical effect of the traditional Chinese medicine group was better than that of the control group(P<0.05). The symptom score, Scr, BUN and 24 h urine protein in the traditional Chinese medicine group were significantly lower than those before treatment, and the GFR in the traditional Chinese medicine group was better than that in the control group(P<0.05). The traditional Chinese medicine group was superior to the control group(P<0.05). ALT and AST were all within the normal range, they had no significant changes before and after treatment(P>0.05). There were no obvious adverse reactions in the traditional Chinese medicine group and the control group before and after treatment.[Conclusion] Shenshuai Formulation combined with western medicine can better protect residual renal function in patients with CKD stage 4, improve the quality of life, and improve clinical efficacy. |
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