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| Efficacy and safety of Jiawei Simiao Powder combined with colchicine for acute gouty arthritis: a Meta-analysis |
| Hits 788 Download times 339 Received:May 19, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2022.05.13 |
| Key Words
Jiawei Simiao Powder;colchicine;acute gouty arthritis;Meta-analysis;randomized controlled trial |
| Author Name | Affiliation | E-mail | | FAN Yihua | Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China | | | LIU Wei | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | fengshiliuwei@163.com | | WEN Xinyan | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | DU Shaopeng | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | ZENG Ping | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WU Yue | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of Jiawei Simiao Powder combined with colchicine in the treatment of acute gouty arthritis.[Methods] China National Knowledge Infrastructure(CNKI), Chinese Biology Medicine(CBM), VIP databases, Wanfang databases, PubMed, Web of Science, The Cochrane Library and EMBASE were searched for randomized controlled trial(RCT) about Jiawei Simiao Powder combined with colchicine for acute gouty arthritis from inception to September, 2020. Two researchers respectively searched the literature, collated relevant information and data, and evaluated the risk of bias in the included randomized controlled trials. Then, the Meta-analysis was completed by Revman 5.3 software.[Results] The 13 RCT involving 1 050 patients were selected by inclusion and exclusion criteria. The results of Meta-analysis showed that:in the experimental groups, total effective rate[RR=1.18, 95%CI(1.12, 1.25), P<0.000 01], joint tenderness[MD=-0.50, 95%CI(-0.58, -0.43), P<0.000 01], joint swelling[MD=-0.49, 95%CI(-0.52, -0.46), P<0.000 01], UA[MD=-79.40, 95%CI(-118.77, -40.04), P<0.000 1], ESR[MD=-9.08, 95%CI (-14.00, -4.16), P=0.000 3] and adverse reaction rate[RR=0.45, 95%CI(0.30, 0.68), P=0.000 1] were better than those of the control group, and the differences were statistically significant.[Conclusion] Current evidence shows that, compared with colchicine alone, the combination of Jiawei Simiao Powder and colchicine in the treatment of acute gouty arthritis has more advantages in terms of the total effective rate, the relief of joint symptoms, the improvement of erythrocyte precipitation index and safety, but the efficacy of blood uric acid cannot be drawn a more reliable conclusion. However, due to the limited number and low quality of the included randomized controlled trials, more randomized, double-blind, large-sample clinical studies are needed to confirm the conclusion. |
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