|
| Study on preparation and law of quality value transmitting of Chuanxiong Dispensing Granules |
| Hits 581 Download times 469 Received:May 15, 2022 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2022.05.18 |
| Key Words
Rhizoma Chuanxiong Standard Decoction;Chuanxiong Dispensing Granules;quantity value transmitting;extraction rate;transfer rate;specific chromatogram |
| Author Name | Affiliation | E-mail | | GAO Yang | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 102400, China
Beijing Tcmages Pharmaceutical Co. LTD., Beijing 101399, China | | | GAO Xiaoyan | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 102400, China | gaoxiaoyan@bucm.edu.cn | | ZHANG Zhiqiang | Beijing Tcmages Pharmaceutical Co. LTD., Beijing 101399, China | |
|
| Abstract
|
| [Objective] Study on preparation and law of quality value transmitting of Chuanxiong Dispensing Granules, the correlation of Rhizoma Chuanxiong decoction pieces, standard decoction and dispensing granules was determined to ensure the equivalence of dispensing granules and standard decoction.[Methods] Eighteen batches of Rhizoma Chuanxiong standard decoction were prepared and the extraction rate was determined.The specific chromatogram was established and the characteristic peaks were identified. The content of ferulic acid in decoction pieces and standard decoction was determined and the transfer rate was calculated. Based on the quality index obtained from the standard decoction, the preparation process was studied to prepare Chuanxiong Dispensing Granules. Taking the paste yield, ferulic acid content, transfer rate and characteristic peak as indexes, the value transfer of Chuanxiong Dispensing Granules was studied.[Results] Through the study of standard decoction of 18 batches of Rhizoma Chuanxiong decoction pieces, the range of extraction rate was determined:26%~37%;a total of 8 characteristic peaks were assessed, and three components wereferulic acid, ligustilide A and ligustilide. Ferulic acid content range was 0.28%~0.52% and the average transfer rate was 37.7%.[Conclusion] There were 8 characteristic peaks in Rhizoma Chuanxiong decoction pieces, standard decoction and dispensing granules, ferulic acid transfer stability. The results showed that all the chemical components in Rhizoma Chuanxiong decoction pieces were basically transferred to dispensing granules, and the Chuanxiong Dispensing Granules were basically equivalent to standard decoction. |
|
|
|
|
|
