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| Regulatory effect of active components of traditional Chinese medicine on tumor cell cycle genes |
| Hits 677 Download times 613 Received:September 10, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2022.06.22 |
| Key Words
traditional Chinese medicine;active component;tumor;cell cycle;gene regulation |
| Author Name | Affiliation | E-mail | | SHEN Qian | Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | | | SHEN Yulei | Beijing University of Traditional Chinese Medicine, Beijing 100029, China | | | ZENG Xueqian | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | LI Junchen | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Jianling | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | jianlingzhang@tjutcm.edu.cn | | PANG Bo | Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | drpangbo@gmail.com |
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| Abstract
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| The abnormal expressions of cell genes are the key gene group for tumor cells carrying defective genes for unlimited proliferation,and they are the clinical targets with great potential. The active components of traditional Chinese medicine are widely concerned because of their remarkable anticancer effect and few adverse reactions. It has been shown that the active components of traditional Chinese medicine can regulate the expressions of Cyclin, CDK and CKI,and inhibit the growth of tumor cells and induce apoptosis. In-depth research can provide molecular biological basis of pharmacodynamic genes for anticancer treatment with traditional Chinese medicine and further clinical application of the active components. |
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