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| QiShen Yiqi Dropping Pill improve left ventricular cardiac function in convalescent period of acute myocardial infarction:a systematic review |
| Hits 628 Download times 837 Received:November 10, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2023.01.14 |
| Key Words
QiShen Yiqi Dropping Pill;recoverable period of acute myocardial infarction;Meta-analysis |
| Author Name | Affiliation | E-mail | | WANG Can | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Baohe | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | wbh3423@126.com | | GU Xufang | Clinical Pharmacology Department, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | guxf218@163.com | | LIU Zhichao | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Lidong | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Shengwei | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | |
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| Abstract
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| [Objective] To evaluate the efficacy of QiShen Yiqi Dropping Pills combined with conventional Western medicine in improving left ventricular cardiac function in the convalescence of acute myocardial infarction (AMI).[Methods] Randomized controlled trials (RCTs) of Qishen Yiqi Dropping Pills combined with conventional Western medicine in the treatment of myocardial infarction in convalescent stage were searched in CNKI,Wan Fang,Wei Pu (VIP),Chinese biomedical literature database (CBMdisc),PubMed,EMbase database and the Cochrane Library. After quality evaluation and effective data extraction,Revman 5.3 software was used for statistical analysis.[Result] A total of 15 qualified RCTs were included,including 1 569 subjects,including 794 in the experimental group and 775 in the control group. The quality of the included literature was generally low. Compared with conventional western medicine treatment,QiShen Yiqi Dropping Pills could improve left ventricular ejection fraction (LVEF) in AMI patients after revascularization[short term treatment (<6 months) P<0.05,MD=5.94,95%CI(3.75, 8.14);long term treatment (≥ 6 months) P<0.05,MD=5.35,95%CI (4.16,6.54)]. In short-term treatment,left ventricular end systolic diameter (LVESD)[P<0.05,MD=-5.56,95%CI (-6.82,-4.30)] or volume(LVESV)[P<0.05,MD=-10.11, 95%CI(-11.73,-8.49)] were smaller. Left ventricular end diastolic diameter (LVEDD) or volume (LVEDV) were smaller[P<0.05,MD=-9.28,95%CI (-11.43,-7.14)].[Conclusion] Compared with conventional western medicine in the treatment of AMI convalescence,QiShen Yiqi Dropping Pills can enhance the cardiac function of patients after revascularization and delay the process of left ventricular remodeling. However,the limitation in quantity and quality of included clinical studies,the results are only used as evidence-based reference for clinical diagnosis and treatment,and more high-quality RCTs are needed to further confirm the curative effect. |
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