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| Advances in the antidepressant effects and mechanisms of traditional Chinese medicine based on glucocorticoid receptor signaling pathway |
| Hits 695 Download times 851 Received:September 25, 2022 |
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| DOI
10.11656/j.issn.1673-9043.2023.01.22 |
| Key Words
depression;Chinese medicine;glucocorticoid;glucocorticoid receptor;mechanism |
| Author Name | Affiliation | E-mail | | HAN Guoying | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Lin | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Nan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Han | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | zhanghan0023@126.com |
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| Abstract
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| The pathogenesis of depression is complex. The depression is typically characterised by abnormally high glucocorticoid (GC) levels and hyperfunction of the hypothalamic-pituitary-adrenal (HPA) axis,which is mainly mediated by the glucocorticoid receptor (GR). This is mainly mediated by the GR. Studies have shown that hyperfunction of the HPA axis,caused by reduced GR function and decreased numbers in depressed patients,is one of the triggers of depression. And antidepressants can improve the abnormal changes in GR,suggesting that GR is a new target for antidepressants. In recent years,Chinese medicine has made great progress in the treatment of depression. This paper reviews the role and mechanism of Chinese medicine based on GR pathway in the treatment of depression,so that it can provide a reference for clinical treatment of depression. |
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