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| Research progress of bacterial resistance mechanism and new drug development strategy |
| Hits 661 Download times 876 Received:November 01, 2022 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2023.01.23 |
| Key Words
MRSA;AB;Chinese medicine antibacterial;resistance mechanism;efflux pump;biofilm;β-lactamase |
| Author Name | Affiliation | E-mail | | XING Lingyi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JING Yaoyao | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Jing | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SONG Xinbo | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Modern Innovative Chinese Medicine Technology Co. Ltd., Tianjin 300191, China | | | LI Wei | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | cheercathy@163.com |
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| Abstract
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| Since the beginning of the 21st century,the abuse of antibiotics has led to the production of many drug-resistant bacteria,even "super bacteria" have appeared. This situation led to clinical infections and the failure of empirical antibiotic therapy. This paper reviews and discusses the current status,trends and mechanisms of bacterial resistance,which takes Methicillin-resistant staphylococcus aureus and Acinetobacter baumannii as examples. Discuss the advantages of traditional Chinese medicine in the treatment of bacterial infections and the new strategies for the development of new antibacterial drugs. Reveal the fundamental principle of bacterial resistance,in order to find a way to reverse and eliminate resistance,provide new ideas for future research on bacterial prevention,treatment of bacterial infections with traditional Chinese medicine,and development of new antibacterial drugs. |
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