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Quality analysis of Pueraria Formula Granules process control based on specific chromatogram
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DOI   10.11656/j.issn.1673-9043.2023.02.17
Key Words   Pueraria standard decoction;specific chromatogram;puerarin;Pueraria;Pueraria Formula Granules
Author NameAffiliationE-mail
WANG Dongyue National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co., Ltd., Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101301, China 312208231@qq.com 
ZHANG Zhiqiang National and Local Joint Engineering Research Center for Key Technology of Chinese Medicinal Composition Granules of Beijing Tcmages Pharmaceutical Co., Ltd., Beijing Engineering Technology Research Center for Chinese Medicinal Composition Granules, Beijing 101301, China  
Abstract
    [Objective] The correlation among Pueraria piece, standard decoction and Formula Granules was analyzed by the specific chromatogram, which to realize the quality analysis of Pueraria Formula Granules process control.[Methods] The specific chromatogram was established by UPLC, the UPLC methods was used to determine the content of puerarin in Pueraria piece, standard decoction and Formula Granules. Meanwhile, the common pattern of the three specific chromatogram was established and the correlation was evaluated through the control specific chromatogram.[Results] The average content of puerarin in 24 batches of Pueraria piece, standard decoction, Formula Granules was 5.8%, 10.3%, 7.8%, respectively. There were 8 common peaks in all specific chromatogram of 24 batches of Pueraria pieces, standard decoction and Formula Granules. The similarity of the three was greater than 0.90, indicating that the material components of the three were basic consistency.[Conclusion] After methodological investigation, the established UPLC specific chromatogram method is stable and accurate. It can evaluate the consistency of Pueraria formula granules and clinical decoction, and provide basis for quality analysis of Pueraria Formula Granules process control.

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