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| Research status of 3D cell microfluidic chip model and its application in drug toxicity evaluation |
| Hits 521 Download times 742 Received:October 22, 2022 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2023.02.21 |
| Key Words
3D cell;microfluidic chip;drug toxicity evaluation;bioprinting;organoid |
| Author Name | Affiliation | E-mail | | ZHU Liying | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | ZHANG Dandan | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | DU Hongying | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | YU Mingxing | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | ZHU Yan | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | yanzhu.harvard@icloud.com |
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| Abstract
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| At present, the traditional cell culture and animal models used for pre-clinical drug screening and evaluation have different degrees of defects. Three-dimensional cell microfluidic chip model as a new research model in vitro, can simulate high tissue physiological structure, function, structure of biochemical and mechanical environment, maintain tissue function is stable, long-term training in physiological and pathological model was constructed, drug screening and regenerative medicine has broad prospects. In this paper, the research progress of 3D cell microfluidic chip model was reviewed. The advantages, feasibility, application cases and existing problems of 3D cell microfluidic chip model were discussed with drug toxicity evaluation as the focus, and the great value and broad application prospects of 3D cell microfluidic chip model were prospected according to the characteristics of traditional Chinese medicine inheritance and innovation research. |
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