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| Study on traditional Chinese medicine syndromes in patients with early renal injury after coronary angiography |
| Hits 521 Download times 651 Received:January 17, 2023 |
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| DOI
10.11656/j.issn.1673-9043.2023.03.01 |
| Key Words
contrast-induced acute kidney injury;contrast-related early kidney injury;traditional Chinese medicine syndrome |
| Author Name | Affiliation | E-mail | | CHENG Liying | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Zhu | Department of Nephrology, Fuwai Central China Cardiovascular Hospital, Zhengzhou 451464, China | | | XING Hui | The First Clinical School of Henan University of Chinese Medicine, Zhengzhou 450064, China | | | YIN Hong | The First Clinical School of Henan University of Chinese Medicine, Zhengzhou 450064, China | | | HUO Shuai | Department of Nephrology, Fuwai Central China Cardiovascular Hospital, Zhengzhou 451464, China | huoshuai1017@163.com |
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| Abstract
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| [Objective] This study aimed to summarize the characteristics of traditional Chinese medicine（TCM） syndromes in patients with early renal injury caused by contrast agents，laying a foundation for the further use of TCM clinical interventions in contrast agent-related renal injury，and provide syndrome reference ideas for preventing CI-AKI. [Methods] One hundred and seventy-two inpatients with normal glomerular tubule function who underwent coronary angiography were selected from September 2020 to December 2020 in Fuwai Central China Cardiovascular Hospital. According to whether the glomerular tubule function was impaired within 24 h after coronary angiography，the 172 patients were divided into injury group with 33 cases and the non-injury group with 139 cases. Then，this study comparedthe demographic characteristics，concomitant underlying diseases，and TCM syndrome distribution between the two groups. Finally，the basic characteristics and TCM syndrome characteristics of patients with early renal injury caused by contrast agents were summarized. [Results] 1）In terms of gender and combined diabetes and hyperlipidemia，there was statistically significant discrepancy between the two groups（P>0.05），the patients of the injury group were more advanced than those of the non-injury group and there were more patients with hypertension in the injury group（P<0.05）. 2）In the comparison of disease characters including pure deficiency syndrome，pure empirical syndrome，and syndrome of mixed void and solid，the discrepancies between the two groups were not statistically significant（P>0.05）. Among the empirical syndrome elements，blood stasis syndrome accounted for the highest proportion in the injury group（46.43%），in terms of deficiency syndrome，the injury group had the highest proportion of qi deficiency syndrome（69.57%）. In the comparison of the basic syndromes in patients of the two groups，the proportions of qi deficiency syndrome and blood stasis syndrome in the injury groupwere larger than that of the non-injury group（P<0.05），the differences between the two groups with respect to the distribution of syndromes such as blood deficiency，yin deficiency，yang deficiency，fever，phlegm dampness，and water stagnation were not statistically significant（P>0.05）. [Conclusion] 1）Patients with advanced age and high blood pressure are more likely to develop early renal injury caused by contrast media. 2）The pathogenesis of early renal injury caused by contrast agent is more complicated，which includes pure deficiency syndrome，pure empirical syndrome，and syndrome of mixed void and solid. Qi deficiency and blood stasis are the more common syndrome factors in patients with renal injury within 24 h after coronary angiography. In clinical practice，the treatment of early kidney injury caused by contrast agents should be based on promoting blood circulation and removing blood stasis，while replenishing qi and nourishing yin，and promoting hydration and phlegm. |
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