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| The efficacy and safety of Fuzheng Huayu Capsule combined with routine liver protection treatment in liver fibrosis:a systematic review and Meta-analysis |
| Hits 445 Download times 668 Received:February 21, 2023 |
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| DOI
10.11656/j.issn.1673-9043.2023.03.08 |
| Key Words
Fuzheng Huayu Capsule;liver fibrosis;randomized controlled trial;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | TIAN Chunying | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HUANG Yang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SUN Xuan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GUAN Yuanyuan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | TIAN Zhikui | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Dongjun | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Hongwu | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | tjwanghw55@163.com |
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| Abstract
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| [Objective] To systematically evaluate the efficacy and safety of Fuzheng Huayu Capsule combined with routine liver protection treatment for liver fibrosis. [Methods] A systematical retrieval was performed through PubMed,EMbase,Cochrane Library,CNKI,WanFang,VIP and SinoMed from the establishment to April 2020. Randomized controlled trials of Fuzheng Huayu Capsule combined with routine liver protection treatment for liver fibrosis were retrieved. Two researchers independently screened the literature,extracted the data and assessed the risk of bias. The RevMan 5.3 software of Cochrane collaboration was used for data analysis. [Results] A total of 12 studies involving 1 032 patients were included. Meta-analysis showed that in the clinical efficacy,Fuzheng Huayu Capsule combined with routine liver protection treatment was superior to routine liver protection treatment alone. In the serological indexes of fibrosis,Fuzheng Huayu Capsule combined with conventional liver protection treatment was superior to conventional liver protection treatment alone. In the liver function indexes(ALT,AST,TBiL and ALB),Fuzheng Huayu Capsule combined with routine liver protection treatment was superior to routine liver protection treatment alone. In the liver function indexes(GLB),Fuzheng Huayu Capsule combined with routine liver care therapy was equivalent to routine liver care therapy alone. In the ultrasound indexes of liver and spleen,Fuzheng Huayu Capsule combined with conventional liver protection treatment was superior to conventional liver protection treatment alone,and no serious adverse reactions occurred. [Conclusion] Based on the current evidence,on the basis of conventional liver protection treatment,Fuzheng Huayu Capsule can further improve the clinical efficacy,improve the serum indexes of liver fibrosis,ALT,AST,TBIL,ALB levels and liver and Spleen Ultrasound indicators (portal vein diameter,splenic vein diameter,spleen thickness),and no serious adverse reactions occurred. However, in improving the level of GLB,Fuzheng Huayu Capsule can improve the level of liver fibrosis The treatment of routine liver protection is equivalent. However,due to the overall low quality of the included studies,the results still need to be verified by standard multi-center large-scale double-blind randomized controlled clinical trials. |
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