|
| A real-world study on the treatment of pulmonary multidrug-resistant bacteria infection after stroke by the benefiting vital qi and strengthening spleen therapy |
| Hits 572 Download times 791 Received:March 05, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2023.04.02 |
| Key Words
stroke-associated pneumonia;multidrug-resistant bacteria;traditional Chinese medicine;real world study |
| Author Name | Affiliation | E-mail | | YANG Linxuan | Clinical Acupuncture Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Linna | Clinical Acupuncture Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Xue | Clinical Acupuncture Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIN Xin | Clinical Acupuncture Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YIN Lili | Clinical Acupuncture Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | kintelili@163.com |
|
| Abstract
|
| [Objective] To observe the clinical efficacy of the formula using benefiting vital Qi and strengthening spleen therapy in treating patients with pulmonary multidrug-resistant bacteria(MDRB) infection after stroke.[Methods] Based on real-world study methods, 113 cases with first diagnosis of pulmonary MDRB infection after stroke between January 2018 and May 2021 were collected retrospectively. They were divided into exposed group(40 cases) and non-exposed group(73 cases) according to whether or not they used the benefiting vital qi and strengthening spleen therapy. The best pairs were generated by propensity score match(PSM) to compare improvements of pneumonia and changes in infection indicators between the two groups,Kaplan-Meier method and Cox regression were used for survival analysis.[Results] After PSM,36 patients were included in each of the two groups,and all indicators were well matched. In the short term,the efficacy of the exposed group was better than that of the non-exposed group,with a statistically significant difference (P<0.05),and the peripheral blood leukocyte count and procalcitonin were significantly lower in the exposed group than in the non-exposed group after treatment,with a statistically significant difference(P<0.05). Long-term prognostic analysis showed that the survival rate within 1 year was higher in the exposed group(77.8%) than in the non-exposed group(47.2%),Log-rank P=0.009,and the use of the formula for benefiting vital Qi and strengthening spleen therapy was a protective factor for the prognosis of pulmonary MDRB infection after stroke(HR=0.423).[Conclusion] The formula using benefiting vital qi and strengthening spleen therapy can improve the short-term outcome and long-term survival of pulmonary MDRB infection after stroke in the real world. |
|
|
|
|
|
