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Research progress on regulation of insomnia with anxiety neurotransmitter secretion by traditional Chinese medicine
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DOI   10.11656/j.issn.1673-9043.2023.04.18
Key Words   traditional Chinese medicine;insomnia with anxiety;neurotransmitter;mechanism of action
Author NameAffiliationE-mail
LI Ying Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
 
LIU Zijia Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine College of Orthopedics and Traumatology, Zhengzhou 450000, China 
 
TANG Mengzhen Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
 
WANG Yani Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
 
GUO Xiang Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
 
ZHANG Jing Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
 
XU Zhibo Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
 
GUO Xianhui Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Henan University of Traditional Chinese Medicine Third Affiliated Hospital, Zhengzhou 450008, China 
gxhhactcm@126.com 
Abstract
    Insomnia,as a public health problem,has attracted much attention and has seriously affected individuals' work and life. With the continuous understanding of the disease,neurotransmitters have been found to have an important regulatory role in the pathogenesis and treatment of insomnia with anxiety. Therefore,the regulation of related mechanisms affects the secretion of neurotransmitters,making it possible to truncate the progression of insomnia with anxiety in the early stage. The treatment of insomnia with anxiety by traditional Chinese medicine(TCM) has been widely used in clinical practice. From the perspective of molecular biology and cell biology,this paper expounds the mechanism of TCM in the treatment of insomnia with anxiety. Current research suggests that TCM can regulate the secretion of neurotransmitters by regulating the body's immune response,intestinal flora,miRNA,intercellular signaling pathways and other pathways. This paper reviews the mechanism of TCM in the regulation of neurotransmitter secretion in insomnia with anxiety,to provide new research ideas for the treatment of insomnia with anxiety by TCM.

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