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| Application of 2D-LC in the analysis of traditional Chinese medicine |
| Hits 504 Download times 1024 Received:March 03, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2023.04.19 |
| Key Words
two-dimensional liquid chromatography;research of traditional Chinese medicine;application progress |
| Author Name | Affiliation | E-mail | | MA Di | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | CHEN Hao | State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Chenxi | State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FU Zhifei | State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HAN Lifeng | State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | hanlifeng@tjutcm.edu.cn |
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| Abstract
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| With the advancement of analytical techniques,two-dimensional liquid chromatography (2D-LC) was appeared based on high performance liquid chromatography. 2D-LC is a separation system which composed of two columns. The columns have different separation mechanisms and independent with each other. Compared with one-dimensional liquid chromatography,2D-LC has the advantages of large peak capacity,strong specificity,high sensitivity,and strong separation ability. 2D-LC has been widely used in pharmaceuticals,food,and other research fields. Due to the ingredients of traditional Chinese medicine(TCM) are very complex,many of them have similar structures and minor differences in polarity,which is difficult to be separated,traditional analytical techniques have some limitations. The invention of 2D-LC has made the analysis of TCM become more convenient,rapid,and comprehensive. It also promoted the development of TCM research. In this paper,the concept and feature of 2D-LC are summarized,and elaborated the application of 2D-LC in analysis of TCM in the past few years,and our work could provide a reference for the future development and application of 2D-LC. |
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