|
| Study on the acute and long-term toxicity of the aerial active parts of Glycyrrhiza uralensis |
| Hits 414 Download times 547 Received:April 30, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2023.05.11 |
| Key Words
aerial active parts of Glycyrrhiza uralensis;acute toxicity;long-term toxicity |
| Author Name | Affiliation | E-mail | | LIU Haifan | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China | | | JI Zuen | Xinjiang Key Laboratory for Research of Licorice and Products, Korla 841011, China
Xinjiang Quan'an Pharmaceutical Co. Ltd., Korla 841011, China | | | PENG Yifeng | Xinjiang Key Laboratory for Research of Licorice and Products, Korla 841011, China
Xinjiang Quan'an Pharmaceutical Co. Ltd., Korla 841011, China | chinn203@126.com | | ZHANG Li | Xinjiang Key Laboratory for Research of Licorice and Products, Korla 841011, China
Xinjiang Quan'an Pharmaceutical Co. Ltd., Korla 841011, China | 923357864@qq.com | | SUN Yanqin | Xinjiang Key Laboratory for Research of Licorice and Products, Korla 841011, China
Xinjiang Quan'an Pharmaceutical Co. Ltd., Korla 841011, China | | | LUO Henglei | Xinjiang Key Laboratory for Research of Licorice and Products, Korla 841011, China
Xinjiang Quan'an Pharmaceutical Co. Ltd., Korla 841011, China | | | ZHANG Wei | Xinjiang Key Laboratory for Research of Licorice and Products, Korla 841011, China
Xinjiang Quan'an Pharmaceutical Co. Ltd., Korla 841011, China | |
|
| Abstract
|
| [Objective] To explore the acute toxicity of the aerial parts of the aerial active parts of Glycyrrhiza uralensis on mice and the long-term toxicity on rats,and evaluate its safety,so as to provide a reliable theoretical basis for the rational development and utilization of the aerial active parts of Glycyrrhiza uralensis and its clinical application. [Methods] The aerial active parts of Glycyrrhiza uralensis (33.2 g/kg) was intragastrically administered to Kunming mice,and the test substance was intragastrically administered twice within 24 h(at an interval of 5 h). The acute toxic reactions in mice within 14 d were continuously observed. SD rats were randomly divided into the control group and low,medium,and high dose groups. The aerial active parts of Glycyrrhiza uralensis were intragastrically administered at the doses of 8.3,16.6 and 33.2 g/kg continuously for 90 d to observe the general condition of the rats. Hematology and serum biochemical indicators were detected 45 and 90 d after the administration,respectively. Gross anatomy and pathology were performed 90 d after the administration to observe the long-term toxic reaction of the aerial active parts of Glycyrrhiza uralensis. [Results] In the acute toxicity test,no abnormality was found in the general state,diet,secretion and defecation of mice,no mouse died,and no obvious abnormality was found in the gross autopsy of heart,liver,spleen and other major organ tissues. In the long-term toxicity test,no significant difference was found in general conditions,hematology and serum biochemical indicators between the groups and the control group. No morphological changes of major organs were found in pathological examination. [Conclusion] The aerial active parts of Glycyrrhiza uralensis has no acute or long-term toxicity,and it is safe to use within the therapeutic dose range. |
|
|
|
|
|
