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| Effect of different penetration enhancers on percutaneous absorption of paeoniflorin in vitro |
| Hits 395 Download times 640 Received:June 08, 2023 |
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| DOI
10.11656/j.issn.1673-9043.2023.05.14 |
| Key Words
paeoniflorin;transdermal absorption;penetration enhancer |
| Author Name | Affiliation | E-mail | | HU Yuankang | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHONG Yuhong | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Zhidong | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lonerliuzd@163.com | | QI Dongli | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | qidongli@tjutcm.edu.cn |
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| Abstract
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| [Objective] To study the physical and chemical properties of paeoniflorin(PF) and the effects of peppermint oil,eucalyptus oil,oleic acid,azone and four penetration enhancers on the percutaneous absorption of PF in PF gel in vitro. [Methods] The apparent solubility and oil-water partition coefficient of PF were determined by shake-flask method,and the concentration of PE in rat skin was determined by HPLC,accumulation of PF and its permeation rate through rat skin. [Results] The 7% peppermint oil,5% peppermint oil,4% eucalyptus oil and 3% oleic acid could improve the transdermal absorption of PF gel,the order of enhancing permeability was 7% peppermint oil >5% peppermint oil >4% eucalyptus oil >3% oleic acid. [Conclusion] The 7% peppermint oil was the best penetration enhancer for PF gel. |
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